Chlamydia Vaccine Could Slow Koala Disease Crisis

By webadmin on 09:52 pm Feb 22, 2012
Category Archive

The koala, one of Australia’s most treasured creatures, is in trouble.

Faced with habitat loss, climate change and bacterial disease, koalas are being pushed into smaller and smaller regions of the country. In Queensland, the vast state in Australia’s northeastern corner, surveys suggest that from 2001 to 2008, their numbers dropped as much as 45 percent in urban areas and 15 percent in bushland.

And while climate change and habitat loss are affecting many other uniquely Australian animals — from birds and frogs to marsupials like wombats, wallabies and bandicoots — it is a bacterial infection that is worrying many scientists about the fate of the koala.

“Disease is a somewhat silent killer and has the very real potential to finish koala populations in Queensland,” said Amber Gillett, a veterinarian at the Australia Zoo Wildlife Hospital in Beerwah, Queensland.

The killer is chlamydia, a class of bacteria far better known for causing venereal disease in humans than for devastating koala populations. Recent surveys in Queensland show that chlamydia has caused symptoms in up to 50 percent of the state’s wild koalas, with probably even more infected but not showing symptoms.

The bacteria — transmitted during birth, through mating and possibly through fighting — come in two different strains, neither the same as the human form.

The first, Chlamydia pecorum, is causing a vast majority of health problems in Queensland’s koalas; the second, Chlamydia pneumoniae, is less common.

Unlike Chlamydia pecorum, the pneumoniae strain can jump to other species, but so far there is no evidence that it has spread from koalas to humans or vice versa.

Chlamydia causes a host of symptoms in koalas, including eye infections, which can lead to blindness, making it difficult for them to find scarce eucalyptus leaves, their primary food source. The bacteria can also lead to respiratory infections, along with cysts that can make female koalas infertile.

The epidemic has been particularly severe in Queensland, where nearly all koalas are infected with koala retrovirus, said Gillett. This retrovirus is an HIV-like infection that suppresses the koala’s immune system and interferes with its ability to fight off chlamydia.

“In southern koala populations, where koala retrovirus is much less prevalent, normal immune functions tend to result in fewer cases,” Gillett said.

Treating chlamydia in wild koalas is a challenge, she said.

The disease is so devastating that only a small percentage of the animals can be treated successfully and returned to the wild. And infected females often become infertile — a condition that cannot be reversed, so future population growth is affected as well.

There is no treatment available for koala retrovirus, but researchers are working to test a vaccine that would help prevent further spread of chlamydia infection in Queensland’s koalas.

Peter Timms, a professor of microbiology at the Queensland University of Technology who is leading the effort to test the chlamydia vaccine in koalas, is hopeful that there will be another trial this year to test the vaccine in captive male koalas, followed by wild koalas. If all goes well, plans can be set in motion to distribute the vaccine more widely.

“It’s going to be impossible to vaccinate all wild koalas,” he said.

Once the vaccine is shown to be completely safe and effective, Timms suggests targeting specific, threatened populations where capturing and releasing koalas would be practical, like those bordered on all sides by housing developments and roads.

Timms is also working on a single-dose form of the vaccine to make it more feasible to vaccinate wild koalas.

Another possibility would be to make vaccine distribution a routine part of treatment for the thousands of koalas brought into care centers every year after they are injured by cars or dogs, Timms said.

It is a combination of problems that are affecting the wild koala population, but many experts believe the vaccine may buy enough time to give researchers a chance to solve some of the other problems facing Australia’s koalas.

“In situations where you combine habitat pressure, domestic dog attacks and car hits with severe chlamydial disease, the outcome for koalas is devastating,” Gillett said.

The New York Times